The truck driver involved in yesterday’s horrific fatal pile-up on the M5 has been arrested and charged, with police investigating if he was using his mobile phone.

The crash happened near the Belmore Road overpass at Riverwood at about 8.20am on Wednesday, involving three cars and a truck.

A 10-year-old boy was killed, his 13-year-old sister was rushed to hospital with head injuries and fractured ribs and his 31-year-old mother suffered minor injuries along with two other women.

A young boy heading to school has been killed, after his family’s car was hit from behind by a semi-trailer this morning, and now police are investigating whether the driver was on the phone at the time. @DamoNews #9News pic.twitter.com/Exm7eO4WoD

— Nine News Sydney (@9NewsSyd) November 27, 2019

Citybound lanes of the M5 was closed for more than six hours as the Crash Investigation Unit examined the scene.

The driver of the Volvo Prime Mover has now been arrested and charged over the incident, with a mobile phone seized for forensic examination.

The 26-year-old man was taken to Bankstown Hospital for mandatory testing before being transferred into police custody.

He’s now been charged with dangerous driving occasioning death and grievous bodily harm, negligent driving occasioning death and grievous bodily harm, and cause bodily harm by misconduct.

He’s been refused bail and will appear in Bankstown Local Court today.

Anyone with information or dashcam footage of the incident is being urged to contact Crime Stoppers on 1800 333 000.

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Image: 9 News Sydney